Colonialism, Regime change, Social Movement, Sovereinty Change, Revolution, War, and many political happenings impact how we do business. In particular, for small and medium sized businesses, the role of local and global politics is important also. Since political happenings at both the local and global levels are not static, it is important to investigate the dynamic changes occurring in local or global politics that shape the development (progress, stagnant, or regress) of entrepreneurial ecosystems in any place, be it a city, a region, or a country. Major political happenings include regime change (e.g., Iran), sovereignty change (e.g., Hong Kong), war (e.g., Lebanon), social movement (e.g., Arab Spring), new nation formation (e.g., Serbia), and many others. While happening locally, these political changes are directly or indirectly impacted by external forces beyond a nation’s political decisions and control. Research on economic development, in particular entrepreneurial ecosystems, focuses mainly on the internal workings of a place within the boundaries of its institutions and its agents. As we know, institutions, both formal and informal, are not static. In fact, the primary antecedent relative to the dynamics of institutions and their changes are political happenings. An example that supports our positioning is the recent re-birth of entrepreneurial activities in many Eastern European countries following the collapse of the Soviet Union where communism had politicized economic life. There is a need for researchers to expand their investigation beyond static institutions to find new concepts for explaining and understanding the influence of macro and dynamic political happenings at home and abroad in the formation of any entrepreneurial ecosystem.